The Santorini volcano island complex (Aegean Sea - Greece) represents a unique structure with dominant presence of the most impressive caldera in the world formed during the volcanic activity of the Minoan times (1644 BC). Due to high tourist activity and related development, and in order to determine safe land uses, the landslide hazard is determined along the caldera slopes based on geomorphological, geological and geotechnical criteria and according to human interventions. Based on the existing infrastructure, development and human activity an assessment of landslide risk is attempted in three levels, low, medium and high. This calibration is important since it prioritizes the areas that need interventions and necessary works in order to minimize the consequences.